منابع مشابه
T-cell tolerance: central and peripheral.
Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity for self-peptide-MHC complexes are positively selected to further differentiate and function in a...
متن کاملMechanisms of peripheral T-cell tolerance.
It is becoming increasingly clear that the control of self-reactivity involves peripheral mechanisms that supplement thymic negative selection. It is now generally accepted that T-cell activation depends upon both T-cell receptor engagement and the delivery of B7-mediated costimulation by specialized antigen presenting cells (APC). In contrast, failure to deliver B7-mediated costimulation can r...
متن کاملCentral Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut
Inflammatory bowel disease (IBD) including Crohn's disease and ulcerative colitis is often precipitated by an abnormal immune response to microbiota due to host genetic aberrancies. Recent studies highlight the importance of the host genome and microflora interactions in the pathogenesis of mucosal inflammation including IBD. Specifically, genome-wide (GWAS) and also next-generation sequencing ...
متن کاملAllogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance.
T regulatory cells (Tregs) represent agents to mediate tolerance to allografts so that the use of immunosuppressive drugs is avoided. In this regard, we previously demonstrated that the adoptive transfer of allogeneic Tregs into IL-2Rbeta(-/-) mice prevented autoimmunity and led to allograft tolerance. Here, we investigated the requirements and mechanisms that favor this long-lasting tolerance....
متن کاملMechanisms and models of peripheral CD4 T cell self-tolerance.
Each response made by our immune system is either to promote or to prevent immune reactivity. That the immune system can successfully achieve both goals under specific biological conditions depends on central and peripheral tolerance mechanisms. Over the years, various experimental systems have been generated to study peripheral CD4 T cell tolerance. The experimental approaches are clearly dive...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2012
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a006957